Depression doesn't respond to standard treatment in about a third of people, which is why psychedelics, mainly psilocybin, the compound in “magic mushrooms”, are now a serious focus in psychiatry. Here's where the evidence actually stands. In trials, psilocybin isn't a daily pill. It's one or two supervised doses given alongside psychological preparation and follow-up therapy. The early research was promising but mixed. A 2021 Johns Hopkins trial found real antidepressant eff